Every treatment, ranked at once.
What it is
Many treatments, one connected network, one ranking.
A pairwise meta-analysis answers A versus B. A network meta-analysis joins every trial into one network, so it can compare A, B, C, and D at once, estimate comparisons no trial ever made, and rank the options by effect and by certainty.
What we run
Frequentist and Bayesian, netmeta in R, or gemtc with informative priors when the network is sparse.
Dose and class level, networks by dose, by drug, or by class, and component analyses for combined treatments.
Ranking with honesty, SUCRA and P-scores reported with their intervals, never as a league table alone.
Consistency checks, transitivity assessed, inconsistency tested by node-splitting, certainty rated with CINeMA.
How it works
The method, in plain terms.
Protocol
PROSPERO, PRISMA-NMA
Search
PubMed, Embase, Scopus
Screen & extract
Two reviewers
Risk of bias
RoB 2, ROBINS-I
Network
Geometry, consistency
Rank & grade
P-scores, CINeMA
How you benefit
Why one network beats ten pairwise reviews.
- One paper answers "which is best". Editors and guideline panels want the whole comparison, not one pair at a time.
- Comparisons no trial has made. Indirect evidence fills the gaps between options that were never tested against each other.
- Defensible under review. Transitivity argued, inconsistency tested, certainty graded. Reviewers see method, not hope.
- No new trial needed. The evidence already exists; we connect it, in months.
The project, step by step
How a network meta-analysis runs with Cohira.
Scope the network
We define the treatments, outcomes, and eligible designs, and check the network is connected and worth building.
Protocol & PROSPERO
We write and register the protocol with the geometry and analysis plan fixed in advance.
Search, screen, extract
We run the search and manage dual screening and extraction with a full audit trail.
Network analysis
We fit the model in R, test consistency, rank the options, and run sensitivity analyses.
Manuscript
We draft the PRISMA-NMA paper with you: network plot, league table, ranking, and certainty.
Submit & revise
We pick the target journal, submit, and answer reviewers with you through to a decision.
Published examples
Our network meta-analyses, in the literature.
Peer-reviewed network meta-analyses co-authored by our researchers, in indexed journals.
Selective aldosterone synthase inhibitors in uncontrolled hypertension: a dose-specific network meta-analysis of randomised trials
Hammad N, et al. · 2026
Dose-level network across six trials and 2,856 patients, with trial sequential analysis and CINeMA certainty.
View in journal →
Optimizing antithrombotic therapy after mitral valve repair: a comprehensive network meta-analysis
Gbreel MI, et al. · 2025
Twelve cohorts and 20,644 patients, ranking antithrombotic strategies never all tested head-to-head.
View in journal →These are peer-reviewed papers co-authored by our researchers. A fuller list is available on request.
Pricing
One fee, from idea to publication.
The fee covers
- Protocol, and registration or ethics submission where the design requires it
- Search, dual screening, extraction, and the analysis
- Journal-ready manuscript, figures, and supplements
- Journal shortlist and the full submission package
- Reviewer responses, every round, to a decision
- A named lead and a second internal reviewer
Billed separately
- Journal fees and APCs, at cost
- Database access or licences, at cost
- Optional Acceptance Guarantee, offered at quotation
Per project, never per author. You get the scope, the week-by-week timeline and a fixed fee in writing within two working days, before you pay anything. Discounts & Acceptance Guarantee →
Start a conversation
More than two options to compare?
Tell us the treatments and the outcome. We will tell you honestly whether the trials connect into a network worth publishing, and how we would build it.