UK Biobank Studies | Cohira Clinical Research

What it is

The most detailed population cohort in the world.

UK Biobank recruited about 500,000 volunteers aged 40 to 69 across the United Kingdom between 2006 and 2010. Each gave blood, urine, and saliva, completed detailed lifestyle and medical questionnaires, and had physical measurements taken.

What it is built for

Scale, 500,000 participants, genotyped, with 10 to 15+ years of linked follow-up.

Design, prospective exposure-outcome cohorts, Mendelian randomisation, polygenic risk scores, prognostic model development and validation.

Limits, healthier and less diverse than the general population; access approval and platform costs take time and must be planned for.

How it works

The method, in plain terms.

01

Access

Application, fields, platform

02

Exposure & outcomes

Baseline data, linked records

03

Build the cohort

Exclusions, missing data

04

Cohort analysis

Cox, dose-response

05

Genetic layers

MR, polygenic scores

06

Reporting

STROBE / STROBE-MR

How you benefit

Why authors start here.

Phenotype depth nothing else matches. Genetics, imaging, biomarkers, and lifestyle on the same people.
Prospective, not retrospective. Exposures measured before outcomes, the design reviewers trust most in observational work.
Causal questions, credibly. Mendelian randomisation lets you ask whether an exposure causes an outcome, not just whether they travel together.
You stay the author. We design and run the study with you to ICMJE standards.

The project, step by step

How a UK Biobank study runs with Cohira.

Start a UK Biobank study →

1

Scope the question

We turn your idea into an exposure-outcome, causal, or prognostic question the cohort can answer.

2

Access plan

We map the application, the fields needed, and the platform steps and costs into a realistic timeline.

3

Protocol

We pre-specify the cohort, outcomes, covariates, and analysis, including any genetic instruments or scores.

4

Analysis

Cohort, Mendelian randomisation, or polygenic analyses in reproducible R or Python code, with the sensitivity checks reviewers expect.

5

Manuscript

We draft a clear paper with you, figures, tables, and limitations reported to STROBE or STROBE-MR.

6

Submit & revise

We shortlist the right journals, package the submission, and answer reviewers with you to a decision.

Published examples

What UK Biobank studies look like in print.

Independent, peer-reviewed examples of what this route can produce.

JAMA CardiologyComparative cohort

Associations of combined genetic and lifestyle risks with incident cardiovascular disease and diabetes in UK Biobank

Said MA, et al. · 2018

Polygenic risk and lifestyle compared across 339,003 participants, genetics and behaviour in one cohort design.

View in journal →

Circ Genom Precis MedMendelian randomisation

Alcohol consumption and cardiovascular disease: a Mendelian randomization study in UK Biobank

Larsson SC, et al. · 2020

Genetic instruments used to test whether alcohol causes cardiovascular disease, the causal design UK Biobank enables.

View in journal →

BMJIllustrative example

Active commuting and incident cardiovascular disease, cancer, and mortality

Celis-Morales CA, et al. · 2017

A prospective analysis of 263,540 participants linking cycling to work with lower cardiovascular and all-cause mortality.

View in journal →

Nature GeneticsIllustrative example

Genome-wide polygenic scores for common diseases identify individuals at monogenic-equivalent risk

Khera AV, et al. · 2018

Polygenic scores validated in UK Biobank identified people at several-fold risk of coronary disease, atrial fibrillation, and diabetes.

View in journal →

NatureResource paper

The UK Biobank resource with deep phenotyping and genomic data

Bycroft C, et al. · 2018

The reference description of the cohort, its genotyping, and its linked data, the paper every UK Biobank study cites.

View in journal →

These are independent published studies, shown to illustrate what UK Biobank makes possible, they are not Cohira's work. We help you design and publish studies of comparable rigor.

Pricing

One fee, from idea to publication.

Database study, idea to publication

Protocol, analysis with reproducible code, manuscript, journal shortlist, submission, and reviewer responses.

$1,800per study

Per project, never per author. Journal fees and database access are billed at cost. UK Biobank access and platform costs are billed at cost. Your week-by-week timeline is written into the free feasibility note before you pay. Booking more than one study? 10% off the second, 15% off from the third. Acceptance Guarantee & group pricing →

More study types

TriNetX NIS / real-world data NRD readmissions Global Burden of Disease SEER cancer registry AI & ML prediction models Meta-analysis Network meta-analyses Diagnostic accuracy meta-analyses Narrative reviews Cross-sectional studies Your clinical data Single stages

Half a million participants, deeply phenotyped.

The most detailed population cohort in the world.